Concepedia

Antigen Processing

Antigen Processing is the intracellular biochemical pathway by which foreign proteins are enzymatically degraded into peptide fragments and subsequently loaded onto major histocompatibility complex molecules for presentation to T lymphocytes, thereby initiating adaptive immune responses.

4K

Publications

289.4K

Citations

13.7K

Authors

2.2K

Institutions

Publications per year

2017–2026

237

Parents

Children

Publications

4K

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

Kenneth L. Rock, Colette F. Gramm, Lisa Rothstein et al. · Cell · 1994 · 2.5K citations

, , +14

Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

Yasutoshi Agata, Hiroyuki Nishimura, Yasumasa Ishida et al. · International Immunology · 1996 · 1.6K citations

, , +10

Differential Antigen Processing by Dendritic Cell Subsets in Vivo

Diana Dudziak, Alice O. Kamphorst, Gordon F. Heidkamp et al. · Science · 2007 · 1.4K citations · Full text

, , +17

Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance

Laura C. Bonifaz, David Bonnyay, Karsten Mahnke et al. · The Journal of Experimental Medicine · 2002 · 1.3K citations · Full text

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Introduction of soluble protein into the class I pathway of antigen processing and presentation

Mark W. Moore, Francis R. Carbone, Michael J. Bevan · Cell · 1988 · 1.1K citations

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1–5 of 4K

Authors

13.7K

  1. KL
    Kenneth L. Rock

    University of Massachusetts Chan Medical School, United States

    55 publications · 10.5K citations

    41

    h-index

  2. JN
    Jacques Neefjes

    The Netherlands Cancer Institute, Netherlands

    42 publications · 5.1K citations

    37

    h-index

  3. CV
    Clifford V. Harding

    Case Western Reserve University, United States

    43 publications · 3.5K citations

    34

    h-index

  4. ER
    Emil R. Unanue

    Washington University in St. Louis, United States

    46 publications · 4.5K citations

    33

    h-index

  5. PC
    Peter Cresswell

    Yale University, United States

    39 publications · 5.4K citations

    32

    h-index

1–5 of 13.7K

Institutions

2.2K

  1. Harvard University

    Cambridge, United States

    83 h-index

    678 publications

    100.4K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    73 h-index

    346 publications

    77.4K citations

  3. National Institutes of Health

    Bethesda, United States

    60 h-index

    428 publications

    39.3K citations

  4. Inserm

    Paris, France

    58 h-index

    719 publications

    59.3K citations

  5. Yale University

    New Haven, United States

    56 h-index

    292 publications

    49.9K citations

  6. National Institute of Allergy and Infectious Diseases

    Bethesda, United States

    53 h-index

    384 publications

    38.8K citations

  7. Heidelberg University

    Heidelberg, Germany

    47 h-index

    250 publications

    22.4K citations

  8. Washington University in St. Louis

    St Louis, United States

    47 h-index

    266 publications

    26.9K citations

1–8 of 2.2K

Venues

  1. The Journal of Experimental Medicine

    219 publications · 29.2K citations

    102

    h-index

  2. The Journal of Immunology

    JI · 567 publications · 37K citations

    101

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 210 publications · 23.4K citations

    91

    h-index

  4. European Journal of Immunology

    EJI · 237 publications · 13.5K citations

    63

    h-index

  5. Journal of Biological Chemistry

    JBC · 176 publications · 11.6K citations

    61

    h-index

1–5