Concepedia

Antibody Affinity Optimization

Antibody Affinity Optimization is a computational and experimental methodology within therapeutic antibody development that specifically enhances the binding strength between an antibody and its target antigen through precise modifications of the antibody’s paratope or epitope interaction interface.

213

Publications

13.2K

Citations

1.5K

Authors

391

Institutions

Publications per year

2017–2026

88

Parents

Publications

213

Engineered antibody Fc variants with enhanced effector function

Greg A. Lazar, Wei Dang, Sher Karki et al. · Proceedings of the National Academy of Sciences · 2006 · 794 citations · Full text

, , +17

Gantenerumab: A Novel Human Anti-Aβ Antibody Demonstrates Sustained Cerebral Amyloid-β Binding and Elicits Cell-Mediated Removal of Human Amyloid-β

Bernd Bohrmann, Karlheinz Baumann, Jörg Benz et al. · Journal of Alzheimer s Disease · 2012 · 450 citations · Full text

, , +17

Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants

Nga Bien‐Ly, Yang Yu, Daniela Bumbaca et al. · The Journal of Experimental Medicine · 2014 · 353 citations · Full text

, , +17

Computational design of antibody-affinity improvement beyond in vivo maturation

Shaun M. Lippow, K. Dane Wittrup, Bruce Tidor · Nature Biotechnology · 2007 · 347 citations · Full text

, , +16

Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning

Derek M. Mason, Simon Friedensohn, Cédric R. Weber et al. · Nature Biomedical Engineering · 2021 · 323 citations · Full text

, , +17

1–5 of 213

Authors

1.5K

  1. KT
    Kouhei Tsumoto

    The University of Tokyo, Japan

    4 publications · 175 citations

    4

    h-index

  2. JB
    Jason Baardsnes

    National Research Council Canada, Canada

    4 publications · 168 citations

    4

    h-index

  3. TS
    Traian Sulea

    Biotechnology Research Institute, Canada

    4 publications · 168 citations

    4

    h-index

  4. LJ
    Lutz Jermutus

    AstraZeneca (Sweden), Sweden

    4 publications · 327 citations

    4

    h-index

  5. PM
    Peter M. Tessier

    Rensselaer Polytechnic Institute, United States

    4 publications · 280 citations

    4

    h-index

1–5 of 1.5K

Institutions

391

  1. Massachusetts Institute of Technology

    Cambridge, United States

    10 h-index

    46 publications

    4.4K citations

  2. Scripps Research Institute

    San Diego, United States

    9 h-index

    41 publications

    2.6K citations

  3. The University of Tokyo

    Tokyo, Japan

    7 h-index

    30 publications

    1.3K citations

  4. Johns Hopkins University

    Baltimore, United States

    6 h-index

    20 publications

    700 citations

  5. University of Oxford

    Oxford, United Kingdom

    6 h-index

    17 publications

    750 citations

  6. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    4 h-index

    10 publications

    1K citations

  7. Xencor (United States)

    Monrovia, United States

    4 h-index

    27 publications

    13.2K citations

  8. Weizmann Institute of Science

    Rehovot, Israel

    4 h-index

    38 publications

    2.9K citations

1–8 of 391

Venues

  1. mAbs

    17 publications · 767 citations

    15

    h-index

  2. Journal of Immunological Methods

    12 publications · 618 citations

    12

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 11 publications · 1.9K citations

    11

    h-index

  4. PLoS ONE

    9 publications · 433 citations

    9

    h-index

  5. Journal of Molecular Biology

    JMB · 9 publications · 518 citations

    9

    h-index

1–5