Derek M. Mason

Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning

Derek M. Mason, Simon Friedensohn, Cédric R. Weber et al. · Nature Biomedical Engineering · 2021 · 295 citations · Full text

Engineering, Machine Learning, Deep Learning +12

High-throughput antibody engineering in mammalian cells by CRISPR/Cas9-mediated homology-directed mutagenesis

Derek M. Mason, Cédric R. Weber, Cristina Parola et al. · Nucleic Acids Research · 2018 · 83 citations · Full text

Engineering, Molecular Biology, Therapeutics +16

A Single-Cell Atlas of Lymphocyte Adaptive Immune Repertoires and Transcriptomes Reveals Age-Related Differences in Convalescent COVID-19 Patients

Florian Bieberich, Rodrigo Vazquez-Lombardi, Alexander Yermanos et al. · Frontiers in Immunology · 2021 · 56 citations · Full text

Deep learning enables therapeutic antibody optimization in mammalian cells by deciphering high-dimensional protein sequence space

Derek M. Mason, Simon Friedensohn, Cédric R. Weber et al. · 2019 · 54 citations · Full text

Engineering, Immunology, Synthetic Immunology +19

Convergent selection in antibody repertoires is revealed by deep learning

Simon Friedensohn, Daniel Neumeier, Tarik A. Khan et al. · 2020 · 47 citations · Full text

Engineering, Adaptive Immune System, Artificial Immune System +24