Computational design of antibody-affinity improvement beyond in vivo maturation

Design of a Novel Globular Protein Fold with Atomic-Level Accuracy

Brian Kuhlman, Gautam Dantas, Gregory C. Ireton et al. · Science · 2003 · 1.7K citations

Life Sciences, Biochemistry, Bioinformatics +15

Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders.

Leonard G. Presta, H Chen, Shane J. O'Connor et al. · PubMed · 1997 · 1.6K citations

Medicine, Oncology, Ophthalmology +17

De Novo Protein Design: Fully Automated Sequence Selection

Bassil I. Dahiyat, Stephen L. Mayo · Science · 1997 · 1.2K citations

Life Sciences, Bioinformatics, Computational Design +15

Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity

Eric T. Boder, Katarina S. Midelfort, K. Dane Wittrup · Proceedings of the National Academy of Sciences · 2000 · 689 citations · Full text

Pharmacy, Biochemistry, Molecular Biology +17

Computational design of receptor and sensor proteins with novel functions

Loren L. Looger, Mary A. Dwyer, James J. Smith et al. · Nature · 2003 · 667 citations

Life Sciences, Bioinformatics, Computational Design +16