Jane R. Kenny

Application of IVIVE and PBPK modeling in prospective prediction of clinical pharmacokinetics: strategy and approach during the drug discovery phase with four case studies

Yuan Chen, Jin Y. Jin, Sophie Mukadam et al. · Biopharmaceutics & Drug Disposition · 2012 · 110 citations

Physiologically Based Pharmacokinetics, Pharmacokinetic Modeling, Preclinical Drug Evaluation +13

A Physiologically Based Pharmacokinetic Modeling Approach to Predict Disease–Drug Interactions: Suppression of CYP3A by IL-6

Krishna K. Machavaram, Lisa M. Almond, Amin Rostami‐Hodjegan et al. · Clinical Pharmacology & Therapeutics · 2013 · 107 citations

Cytokine Levels, Immunology, Physiologically-based Pharmacokinetic Modeling +20

In Vitro–In Vivo Extrapolation of Clearance: Modeling Hepatic Metabolic Clearance of Highly Bound Drugs and Comparative Assessment with Existing Calculation Methods

Patrick Poulin, Jane R. Kenny, Cornelis E. C. A. Hop et al. · Journal of Pharmaceutical Sciences · 2011 · 105 citations

Physiologically-based Pharmacokinetic Modeling, Pharmacodynamic Modeling, Vitro–in Vivo Extrapolation +16

EVALUATION OF TIME-DEPENDENT CYTOCHROME P450 INHIBITION USING CULTURED HUMAN HEPATOCYTES

Dermot F. McGinnity, Amanda J. Berry, Jane R. Kenny et al. · Drug Metabolism and Disposition · 2006 · 99 citations

Syntheses and Characterization of the Acyl Glucuronide and Hydroxy Metabolites of Diclofenac

Jane R. Kenny, James L. Maggs, Xiaoli Meng et al. · Journal of Medicinal Chemistry · 2004 · 99 citations