Sophie Mukadam

Application of IVIVE and PBPK modeling in prospective prediction of clinical pharmacokinetics: strategy and approach during the drug discovery phase with four case studies

Yuan Chen, Jin Y. Jin, Sophie Mukadam et al. · Biopharmaceutics & Drug Disposition · 2012 · 110 citations

Physiologically Based Pharmacokinetics, Pharmacokinetic Modeling, Preclinical Drug Evaluation +13

Prediction of Drug-Drug Interactions Arising from CYP3A induction Using a Physiologically Based Dynamic Model

Lisa M. Almond, Sophie Mukadam, I. Gardner et al. · Drug Metabolism and Disposition · 2016 · 99 citations · Full text

Drug–Drug Interaction Potential of Marketed Oncology Drugs: In Vitro Assessment of Time-Dependent Cytochrome P450 Inhibition, Reactive Metabolite Formation and Drug–Drug Interaction Prediction

Jane R. Kenny, Sophie Mukadam, Chenghong Zhang et al. · Pharmaceutical Research · 2012 · 94 citations

Drug Interactions, Marketed Oncology Drugs, Preclinical Drug Evaluation +10

Discovery of Novel PI3-Kinase δ Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition

Brian S. Safina, Stewart Baker, Matt Baumgardner et al. · Journal of Medicinal Chemistry · 2012 · 66 citations · Full text

Drug Target, Immunology, Inflammatory Arthritis +25

Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349

Zhonghua Pei, Elizabeth Blackwood, Lichuan Liu et al. · ACS Medicinal Chemistry Letters · 2012 · 46 citations · Full text

Drug Target, Chemoprevention Strategy, Advanced Lead 1 +21