Stewart Baker

The Identification of 2-(1<i>H</i>-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-<i>d</i>]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer

Adrian Folkes, Khatereh Ahmadi, W. Alderton et al. · Journal of Medicinal Chemistry · 2008 · 739 citations · Full text

Pi3 Kinase, Chemoprevention Strategy, Pharmacotherapy +18

Design, synthesis, and antiviral properties of 4′-substituted ribonucleosides as inhibitors of hepatitis C virus replication: The discovery of R1479

David B. Smith, Joseph A. Martin, Klaus Klumpp et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 96 citations

Viral Replication, Biochemistry, Natural Sciences +11

Discovery of Novel PI3-Kinase δ Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition

Brian S. Safina, Stewart Baker, Matt Baumgardner et al. · Journal of Medicinal Chemistry · 2012 · 66 citations · Full text

Drug Target, Immunology, Inflammatory Arthritis +25

Potent and selective inhibitors of PI3Kδ: Obtaining isoform selectivity from the affinity pocket and tryptophan shelf

Daniel P. Sutherlin, Stewart Baker, Angelina Bisconte et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 50 citations · Full text

Biochemistry, Functional Selectivity, Medicine +8

Design and Synthesis of New Templates Derived from Pyrrolopyrimidine as Selective Multidrug-Resistance-Associated Protein Inhibitors in Multidrug Resistance

Shouming Wang, Nan Chi Wan, John Harrison et al. · Journal of Medicinal Chemistry · 2004 · 44 citations · Full text

Combinatorial Chemistry, Novel Templates, Multidrug Resistance +17