Brian S. Safina

A Mild and Selective Method for the Hydrolysis of Esters with Trimethyltin Hydroxide

K. C. Nicolaou, Anthony A. Estrada, Mark Zak et al. · Angewandte Chemie International Edition · 2005 · 374 citations

Engineering, Chemical Engineering, Enzymology +3

Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist

Shivani Ahuja, Susmith Mukund, Lunbin Deng et al. · Science · 2015 · 327 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Immune-stimulating antibody conjugates elicit robust myeloid activation and durable antitumor immunity

Shelley E. Ackerman, Cecelia I. Pearson, Joshua D. Gregorio et al. · Nature Cancer · 2020 · 203 citations · Full text

Medicine, Immunology, Oncology +16

Discovery and Preclinical Pharmacology of a Selective ATP-Competitive Akt Inhibitor (GDC-0068) for the Treatment of Human Tumors

James F. Blake, Rui Xu, Josef R. Bencsik et al. · Journal of Medicinal Chemistry · 2012 · 188 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment

Alessia Balestrini, Victory Joseph, Michelle Dourado et al. · The Journal of Experimental Medicine · 2021 · 136 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +15