A Mild and Selective Method for the Hydrolysis of Esters with Trimethyltin Hydroxide

K. C. Nicolaou, Anthony A. Estrada, Mark Zak, +2

Angewandte Chemie International Edition

Derivative (Chemistry)Trimethyltin HydroxideEngineeringBiochemistrySelective Method +9

Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

Georgia Hatzivassiliou, Jacob R. Haling, Huifen Chen, +18

Nature

OncologyMedicineReceptor Tyrosine KinaseCancer GeneticsRadiation Oncology +4

Total Synthesis of Thiostrepton. Retrosynthetic Analysis and Construction of Key Building Blocks

K. C. Nicolaou, Brian S. Safina, Mark Zak, +7

Journal of the American Chemical Society

A Restricted Role for TYK2 Catalytic Activity in Human Cytokine Responses Revealed by Novel TYK2-Selective Inhibitors

Sue J. Sohn, Kathy Barrett, Anne van Abbema, +21

The Journal of Immunology

T-regulatory CellImmunologyImmune RegulationCell DeathImmunologic Mechanism +23

Universal Solid-Phase Approach for the Immobilization, Derivatization, and Resin-to-Resin Transfer Reactions of Boronic Acids

Michel Gravel, Kim A. Thompson, Mark Zak, +2

The Journal of Organic Chemistry

A Mild and Selective Method for the Hydrolysis of Esters with Trimethyltin Hydroxide

K. C. Nicolaou, Anthony A. Estrada, Mark Zak, +2

Angewandte Chemie

Total Synthesis of Thiostrepton, Part 1: Construction of the Dehydropiperidine/Thiazoline‐Containing Macrocycle

K. C. Nicolaou, Brian S. Safina, Mark Zak, +2

Angewandte Chemie International Edition

Bioorganic ChemistryMolecular BiologyOrganic ChemistryChemistryHeterocycle Chemistry +18

Total Synthesis of Thiostrepton. Assembly of Key Building Blocks and Completion of the Synthesis

K. C. Nicolaou, Mark Zak, Brian S. Safina, +3

Journal of the American Chemical Society

Total Synthesis of Thiostrepton, Part 2: Construction of the Quinaldic Acid Macrocycle and Final Stages of the Synthesis

K. C. Nicolaou, Mark Zak, Brian S. Safina, +2

Angewandte Chemie International Edition

Bioorganic ChemistryOrganic ChemistryPeptide ScienceChemistryHeterocycle Chemistry +20

Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors

Janusz J. Kulagowski, Wade Blair, Richard J. Bull, +27

Journal of Medicinal Chemistry

RheumatologyMedicinal ChemistryDrug TargetBiochemistryMedicine +13