Yuan Chen

Physiologically‐Based Pharmacokinetic Modeling in Renal and Hepatic Impairment Populations: A Pharmaceutical Industry Perspective

Tycho Heimbach, Yuan Chen, Jun Chen et al. · Clinical Pharmacology & Therapeutics · 2020 · 125 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17

Application of IVIVE and PBPK modeling in prospective prediction of clinical pharmacokinetics: strategy and approach during the drug discovery phase with four case studies

Yuan Chen, Jin Y. Jin, Sophie Mukadam et al. · Biopharmaceutics & Drug Disposition · 2012 · 110 citations

Pharmacy, Clinical Pharmacokinetics, Pharmacology +12

Utility of Intersystem Extrapolation Factors in Early Reaction Phenotyping and the Quantitative Extrapolation of Human Liver Microsomal Intrinsic Clearance Using Recombinant Cytochromes P450

Yuan Chen, Liling Liu, Khanh Hoang Nguyen et al. · Drug Metabolism and Disposition · 2010 · 99 citations

Medicine, Pharmacokinetics, Pharmacology +17

Using Chimeric Mice with Humanized Livers to Predict Human Drug Metabolism and a Drug-Drug Interaction

Toshihiko Nishimura, Yajing Hu, Manhong Wu et al. · Journal of Pharmacology and Experimental Therapeutics · 2012 · 60 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

Determination of Time-Dependent Inactivation of CYP3A4 in Cryopreserved Human Hepatocytes and Assessment of Human Drug-Drug Interactions

Yuan Chen, Liling Liu, Mario Monshouwer et al. · Drug Metabolism and Disposition · 2011 · 60 citations

Pharmacy, Pharmacokinetics, Pharmacology +15