Mario Monshouwer

Unbound Drug Concentration in Brain Homogenate and Cerebral Spinal Fluid at Steady State as a Surrogate for Unbound Concentration in Brain Interstitial Fluid

Xingrong Liu, Kristine Van Natta, Helen Yeo et al. · Drug Metabolism and Disposition · 2008 · 180 citations

Medicine, Pharmacokinetics, Pharmacology +14

Metabolism: A Bottleneck in <i>In Vitro</i> Toxicological Test Development

Sandra Coecke, H J Ahr, Bas J. Blaauboer et al. · Alternatives to Laboratory Animals · 2006 · 177 citations

Pharmacy, Pharmacokinetics, Toxicology +6

The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death

Laleh Kamalian, Amy E. Chadwick, Mark Bayliss et al. · Toxicology in Vitro · 2015 · 154 citations · Full text

Life Sciences, Cell Biology, Toxicology +17

Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines

Ruben Boon, Manoj Kumar, Tine Tricot et al. · Nature Communications · 2020 · 132 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Suppression of Cytochrome P450- and UDP Glucuronosyl Transferase-Dependent Enzyme Activities by Proinflammatory Cytokines and Possible Role of Nitric Oxide in Primary Cultures of Pig Hepatocytes

Mario Monshouwer, Renger F. Witkamp, Sandra M. Nijmeijer et al. · Toxicology and Applied Pharmacology · 1996 · 118 citations

Medicine, Biochemistry, Cell Biology +17