Human hepatic organoids for the analysis of human genetic diseases

Yuan Guan, Dan Xu, Phillip M. Garfin, +9

JCI Insight

EngineeringGeneticsPathologyBile Duct FormationOrgan Development +23

Quantitative CRISPR interference screens in yeast identify chemical-genetic interactions and new rules for guide RNA design

Justin Smith, Sundari Suresh, Ulrich Schlecht, +7

Genome biology

Involvement of nitric oxide and nitrosothiols in relaxation of pulmonary arteries to peroxynitrite

Manhong Wu, Kirkwood A. Pritchard, Pawel M. Kaminski, +3

American Journal of Physiology-Heart and Circulatory Physiology

Pulmonary Arterial HypertensionPulmonary CirculationNitric OxidePulmonary ArteryPhysiology +10

A human multi-lineage hepatic organoid model for liver fibrosis

Yuan Guan, Annika Enejder, Meiyue Wang, +13

Nature Communications

Metabolomic-derived novel cyst fluid biomarkers for pancreatic cysts: glucose and kynurenine

Walter G. Park, Manhong Wu, Raffick A.R. Bowen, +14

Gastrointestinal Endoscopy

Pancreatic CancerPancreatic Fluid CollectionMedicineBioanalysisGastroenterology +6

Using Chimeric Mice with Humanized Livers to Predict Human Drug Metabolism and a Drug-Drug Interaction

Toshihiko Nishimura, Yajing Hu, Manhong Wu, +16

Journal of Pharmacology and Experimental Therapeutics

The phosphatidylethanolamine biosynthesis pathway provides a new target for cancer chemotherapy

Yuan Guan, Xinyu Chen, Manhong Wu, +8

Journal of Hepatology

Tumor BiologyDrug TargetingSignal TransductionMedicineReceptor Tyrosine Kinase +10

Dysregulated Lipid Synthesis by Oncogenic IDH1 Mutation Is a Targetable Synthetic Lethal Vulnerability

Danièl Thomas, Manhong Wu, Yusuke Nakauchi, +13

Cancer Discovery

Profiling of ARDS pulmonary edema fluid identifies a metabolically distinct subset

Angela J. Rogers, Kévin Contrepois, Manhong Wu, +4

American Journal of Physiology-Lung Cellular and Molecular Physiology

Acute Lung InjuryPulmonary Arterial HypertensionPulmonary CirculationEdema FluidPhysiology +11

Chimeric TK-NOG Mice: A Predictive Model for Cholestatic Human Liver Toxicity

Dan Xu, Manhong Wu, Sachiko Nishimura, +11

Journal of Pharmacology and Experimental Therapeutics