Yuan Chen

A Multifactorial Approach to Hepatobiliary Transporter Assessment Enables Improved Therapeutic Compound Development

Ryan E. Morgan, Carlo J. van Staden, Yuan Chen et al. · Toxicological Sciences · 2013 · 235 citations · Full text

Immunology, Biomedical Engineering, Oxidative Stress +25

Safety, Efficacy, and Pharmacokinetics of Almonertinib (HS-10296) in Pretreated Patients With EGFR-Mutated Advanced NSCLC: A Multicenter, Open-label, Phase 1 Trial

James Chih‐Hsin Yang, D. Ross Camidge, Cheng‐Ta Yang et al. · Journal of Thoracic Oncology · 2020 · 149 citations · Full text

Pretreated Patients, Novel Therapy, Medicine +8

Use of Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Drug-Food Interactions: an Industry Perspective

Arian Emami Riedmaier, Kevin DeMent, James E. Huckle et al. · The AAPS Journal · 2020 · 93 citations · Full text

Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation

Emily J. Hanan, Charles Eigenbrot, Marian C. Bryan et al. · Journal of Medicinal Chemistry · 2014 · 61 citations · Full text

Broad Kinase Selectivity, Drug Target, Molecular Biology +21

Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study

Robert A. Heald, Krista K. Bowman, Marian C. Bryan et al. · Journal of Medicinal Chemistry · 2015 · 55 citations · Full text