Kevin DeMent

Use of Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Drug-Food Interactions: an Industry Perspective

Arian Emami Riedmaier, Kevin DeMent, James E. Huckle et al. · The AAPS Journal · 2020 · 93 citations · Full text

Nonselective inhibition of the epigenetic transcriptional regulator BET induces marked lymphoid and hematopoietic toxicity in mice

Dong U. Lee, Paula Katavolos, Gopinath S. Palanisamy et al. · Toxicology and Applied Pharmacology · 2016 · 43 citations

Knockout Mouse, Chromatin, Transcriptional Regulation +11

Aminoisoxazoles as Potent Inhibitors of Tryptophan 2,3-Dioxygenase 2 (TDO2)

Zhonghua Pei, Rohan Mendonca, Lewis Gazzard et al. · ACS Medicinal Chemistry Letters · 2018 · 39 citations · Full text

Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors

Marian C. Bryan, Joy Drobnick, Alberto Gobbi et al. · Journal of Medicinal Chemistry · 2019 · 30 citations · Full text

Medicinal Chemistry, Drug Target, Biochemistry +13

Improved anti-tumor immunity and efficacy upon combination of the IDO1 inhibitor GDC-0919 with anti-PD-l1 blockade versus anti-PD-l1 alone in preclinical tumor models

Jessica Spahn, Jing Peng, Edward Lorenzana et al. · Journal for ImmunoTherapy of Cancer · 2015 · 28 citations · Full text

Immunology, Immune Regulation, Immunotherapy +22