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In Vitro–In Vivo Extrapolation of Clearance: Modeling Hepatic Metabolic Clearance of Highly Bound Drugs and Comparative Assessment with Existing Calculation Methods

Physiologically-based Pharmacokinetic ModelingPharmacodynamic ModelingVitro–in Vivo ExtrapolationHepatotoxicityDrug AbsorptionHighly Bound DrugsHealth SciencesComparative AssessmentPharmacokinetic ModelingPreclinical Drug EvaluationLiver PhysiologyPharmacologyDrug-induced Liver InjuryHepatologyPhysiologyMetabolismMedicinePharmacokineticsQuantitative Pharmacology