Cornelis E. C. A. Hop

THE IMPACT OF P-GLYCOPROTEIN ON THE DISPOSITION OF DRUGS TARGETED FOR INDICATIONS OF THE CENTRAL NERVOUS SYSTEM: EVALUATION USING THE MDR1A/1B KNOCKOUT MOUSE MODEL

Angela C. Doran, R. Scott Obach, Bill J. Smith et al. · Drug Metabolism and Disposition · 2004 · 440 citations

Plasma-Pooling Methods To Increase Throughput for in Vivo Pharmacokinetic Screening

Cornelis E. C. A. Hop, Zhen Wang, Qing Chen et al. · Journal of Pharmaceutical Sciences · 1998 · 252 citations

Increase Throughput, Pharmacokinetic Modeling, Preclinical Drug Evaluation +7

Interindividual Variability in Hepatic Organic Anion-Transporting Polypeptides and P-Glycoprotein (ABCB1) Protein Expression: Quantification by Liquid Chromatography Tandem Mass Spectroscopy and Influence of Genotype, Age, and Sex

Bhagwat Prasad, Raymond Evers, Anshul Gupta et al. · Drug Metabolism and Disposition · 2013 · 193 citations · Full text

Interspecies Variability in Expression of Hepatobiliary Transporters across Human, Dog, Monkey, and Rat as Determined by Quantitative Proteomics

Li Wang, Bhagwat Prasad, Laurent Salphati et al. · Drug Metabolism and Disposition · 2014 · 187 citations

BIOACTIVATION OF THE NONTRICYCLIC ANTIDEPRESSANT NEFAZODONE TO A REACTIVE QUINONE-IMINE SPECIES IN HUMAN LIVER MICROSOMES AND RECOMBINANT CYTOCHROME P450 3A4

Amit S. Kalgutkar, Alfin D. N. Vaz, Mary E. Lame et al. · Drug Metabolism and Disposition · 2004 · 154 citations