EVALUATION OF TIME-DEPENDENT CYTOCHROME P450 INHIBITION USING CULTURED HUMAN HEPATOCYTES

CYP3A4 Induction by Drugs: Correlation between a Pregnane X Receptor Reporter Gene Assay and CYP3A4 Expression in Human Hepatocytes

Gang Luo, Mark R. Cunningham, Sean Kim et al. · Drug Metabolism and Disposition · 2002 · 447 citations

Medicine, Pharmacology, Biochemical Pharmacology +15

Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes.

Lydiane Pichard, Isabelle Fabre, Gérard Fabre et al. · Drug Metabolism and Disposition · 1990 · 437 citations

Medicine, Pharmacology, Toxicology +17

The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties

Rupert P. Austin, Patrick Barton, Scott L. Cockroft et al. · Drug Metabolism and Disposition · 2002 · 407 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine

U. Jeppesen, L. F. Gram, Kirsten Vistisen et al. · European Journal of Clinical Pharmacology · 1996 · 321 citations

Medicine, Pharmacokinetics, Pharmacology +12

An In Vitro Model for Predicting In Vivo Inhibition of Cytochrome P450 3A4 by Metabolic Intermediate Complex Formation

David R. Jones, Stephen D. Hall · Drug Metabolism and Disposition · 2000 · 294 citations

Medicine, Pharmacokinetics, Pharmacology +17