Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.

Marguerite A. Butler, M. Iwasaki, F. Peter Guengerich et al. · Proceedings of the National Academy of Sciences · 1989 · 638 citations · Full text

Medicine, Pharmacology, Toxicology +17

The effect of selective serotonin re‐uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes.

H.K. Crewe, MS Lennard, GT Tucker et al. · British Journal of Clinical Pharmacology · 1992 · 471 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

Fluvoxamine is a potent inhibitor of cytochrome P4501A2

Kim Brøsen, Erik Skjelbo, Birgitte Buur Rasmussen et al. · Biochemical Pharmacology · 1993 · 372 citations

Medicine, Pharmacokinetics, Pharmacology +13

Evidence That CYP2C19 is the Major (S)-Mephenytoin 4'-Hydroxylase in Humans

Jorge Goldstein, M B Faletto, M Romkes-Sparks et al. · Biochemistry · 1994 · 363 citations

Medicine, Biochemistry, Pharmacology +10

Isolation and Characterization of Human Liver Cytochrome P450 2C19: Correlation between 2C19 and S-Mephenytoin 4′-Hydroxylation

Steven Wrighton, Jeffrey Stevens, Gerald W. Becker et al. · Archives of Biochemistry and Biophysics · 1993 · 283 citations

Medicine, Biochemistry, Pharmacology +11