Annette M. Doherty

Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor

David W. Fry, Alexander J. Bridges, William A. Denny et al. · Proceedings of the National Academy of Sciences · 1998 · 418 citations

Life Sciences, Biochemistry, Pharmacology +17

Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors

William C. Patt, Harriet W. Hamilton, Michael D. Taylor et al. · Journal of Medicinal Chemistry · 1992 · 373 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901

Stephen D. Barrett, Alexander J. Bridges, David T. Dudley et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 286 citations

Pharmacy, Medicinal Chemistry, Pharmacology +9

Structure−Activity Relationships for a Novel Series of Pyrido[2,3-<i>d</i>]pyrimidine Tyrosine Kinase Inhibitors

James M. Hamby, Cleo J. C. Connolly, Mel C. Schroeder et al. · Journal of Medicinal Chemistry · 1997 · 142 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

2-Substituted Aminopyrido[2,3-<i>d</i>]pyrimidin-7(8<i>H</i>)-ones. Structure−Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity

S. KLUTCHKO, James M. Hamby, Diane H. Boschelli et al. · Journal of Medicinal Chemistry · 1998 · 130 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17