James M. Hamby

Structure−Activity Relationships for a Novel Series of Pyrido[2,3-<i>d</i>]pyrimidine Tyrosine Kinase Inhibitors

James M. Hamby, Cleo J. C. Connolly, Mel C. Schroeder et al. · Journal of Medicinal Chemistry · 1997 · 141 citations · Full text

Pharmacotherapy, Compound Library, Heterocycle Chemistry +18

2-Substituted Aminopyrido[2,3-<i>d</i>]pyrimidin-7(8<i>H</i>)-ones. Structure−Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity

S. KLUTCHKO, James M. Hamby, Diane H. Boschelli et al. · Journal of Medicinal Chemistry · 1998 · 130 citations · Full text

In Vitro Pharmacological Characterization of PD 166285, a New Nanomolar Potent and Broadly Active Protein Tyrosine Kinase Inhibitor

Robert L. Panek, Gina H. Lu, S. KLUTCHKO et al. · Journal of Pharmacology and Experimental Therapeutics · 1997 · 94 citations

In Vitro Biological Characterization and Antiangiogenic Effects of PD 166866, a Selective Inhibitor of the FGF-1 Receptor Tyrosine Kinase

Robert L. Panek, Gina H. Lu, Tawny K. Dahring et al. · Journal of Pharmacology and Experimental Therapeutics · 1998 · 88 citations · Full text

Development of a Binding Model to Protein Tyrosine Kinases for Substituted Pyrido[2,3-<i>d</i>]pyrimidine Inhibitors

Susanne Trumpp-Kallmeyer, John R. Rubin, Christine Humblet et al. · Journal of Medicinal Chemistry · 1998 · 85 citations · Full text

Drug Target, Chemical Biology, Pharmaceutical Chemistry +18