Structure−Activity Relationships for a Novel Series of Pyrido[2,3-<i>d</i>]pyrimidine Tyrosine Kinase Inhibitors

James M. Hamby, Cleo J. C. Connolly, Mel C. Schroeder, +18

Journal of Medicinal Chemistry

PharmacotherapyCompound LibraryHeterocycle ChemistryChemical BiologyPharmaceutical Chemistry +16

2-Substituted Aminopyrido[2,3-<i>d</i>]pyrimidin-7(8<i>H</i>)-ones. Structure−Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity

S. KLUTCHKO, James M. Hamby, Diane H. Boschelli, +22

Journal of Medicinal Chemistry

In Vitro Pharmacological Characterization of PD 166285, a New Nanomolar Potent and Broadly Active Protein Tyrosine Kinase Inhibitor

Robert L. Panek, Gina H. Lu, S. KLUTCHKO, +6

Journal of Pharmacology and Experimental Therapeutics

In Vitro Biological Characterization and Antiangiogenic Effects of PD 166866, a Selective Inhibitor of the FGF-1 Receptor Tyrosine Kinase

Robert L. Panek, Gina H. Lu, Tawny K. Dahring, +4

Journal of Pharmacology and Experimental Therapeutics

Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8<i>H</i>-pyrido[2,3-<i>d</i>]pyrimidines:  Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors

Diane H. Boschelli, Zhipei Wu, S. KLUTCHKO, +18

Journal of Medicinal Chemistry

Combinatorial ChemistryBioorganic ChemistryPharmacotherapyCompound LibraryChemical Biology +15

Structure−Activity Relationships for 1-Phenylbenzimidazoles as Selective ATP Site Inhibitors of the Platelet-Derived Growth Factor Receptor

Brian D. Palmer, Jeff B. Smaill, Maruta Boyd, +12

Journal of Medicinal Chemistry

Soluble 2-Substituted Aminopyrido[2,3-<i>d</i>]pyrimidin-7-yl Ureas. Structure−Activity Relationships against Selected Tyrosine Kinases and Exploration of in Vitro and in Vivo Anticancer Activity

Mel C. Schroeder, James M. Hamby, Cleo J. C. Connolly, +17

Journal of Medicinal Chemistry

Tumor Growth DelayChemical BiologyPharmaceutical ChemistryMolecular PharmacologyMedicinal Chemistry +16

The Discovery of (2<i>R</i>,4<i>R</i>)‐<i>N</i>‐(4‐chlorophenyl)‐<i>N</i>‐ (2‐fluoro‐4‐(2‐oxopyridin‐1(2<i>H</i>)‐yl)phenyl)‐4‐methoxypyrrolidine‐1,2‐dicarboxamide (PD 0348292), an Orally Efficacious Factor Xa Inhibitor

Jeffrey T. Kohrt, Christopher F. Bigge, John W. Bryant, +19

Chemical Biology & Drug Design

Pharmaceutical SciencePharmacotherapyChemical BiologyPharmaceutical ChemistryMolecular Pharmacology +14

PDGF Receptor Protein Tyrosine Kinase Expression in the Balloon-Injured Rat Carotid Artery

Robert L. Panek, Tawny K. Dahring, Bronia Olszewski, +1

Arteriosclerosis Thrombosis and Vascular Biology

Vascular DiseaseThrombosisAngiogenesisReceptor Gene ExpressionNeurology +15

INHIBITION OF FGF-1 RECEPTOR TYROSINE KINASE ACTIVITY BY PD 161570, A NEW PROTEIN-TYROSINE KINASE INHIBITOR

Brian L. Batley, Annette M. Doherty, James M. Hamby, +6

Life Sciences

Signal TransductionSignaling PathwayMedicineReceptor Tyrosine KinaseFibroblast Growth Factor +5