2-Substituted Aminopyrido[2,3-<i>d</i>]pyrimidin-7(8<i>H</i>)-ones. Structure−Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity

S. KLUTCHKO, James M. Hamby, Diane H. Boschelli, +22

Journal of Medicinal Chemistry

Cell Cycle and Biochemical Effects of PD 0183812

David W. Fry, David C. Bedford, Patricia H. Harvey, +7

Journal of Biological Chemistry

Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8<i>H</i>-pyrido[2,3-<i>d</i>]pyrimidines:  Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors

Diane H. Boschelli, Zhipei Wu, S. KLUTCHKO, +18

Journal of Medicinal Chemistry

Combinatorial ChemistryBioorganic ChemistryPharmacotherapyCompound LibraryChemical Biology +15

Two Prodrugs of Potent and Selective GluR5 Kainate Receptor Antagonists Actives in Three Animal Models of Pain

Esteban Domı́nguez, Smriti Iyengar, Harlan E. Shannon, +24

Journal of Medicinal Chemistry

Pain TherapyPain MedicineNeuropathic PainMolecular PainPharmacotherapy +17

Discovery of <i>N</i>-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3<i>R</i>)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model

Kevin R. Fales, F. George Njoroge, Harold B. Brooks, +21

Journal of Medicinal Chemistry

PharmacotherapyCancer Xenograft ModelPharmaceutical ChemistryTumor BiologyMolecular Pharmacology +16

High-performance liquid Chromatographic separation of the enantiomers of N-aryloxazolinones, N-aryl thiazolinones and their sulfur derivatives on a synthetic chiral stationary phase

William H. Pirkle, Michael E. Koscho, Zhipei Wu

Journal of Chromatography A

Enantioselective SynthesisEngineeringMedicineN-aryl ThiazolinonesOrganic Chemistry +9

Synthesis and structure–activity relationships of novel dipeptides and reduced dipeptides as ligands for melanocortin subtype-4 receptor

Qing Shi, Paul L. Ornstein, Karin Briner, +21

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyBiochemistryFunctional SelectivityMedicineNatural Sciences +9

Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models

Harold B. Brooks, Timothy I. Meier, Sandaruwan Geeganage, +24

Scientific Reports

A facile route to silver–cadmium sulfide core–shell nanoparticles and their nonlinear optical properties

Xiuli Fu, Zhipei Wu, Ming Lei, +4

Materials Letters

NanoparticlesMaterials ScienceOptical MaterialsNonlinear Optical PropertiesEngineering +8

GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: In vitro profile and in vivo analgesic efficacy

José Antonio Martínez-Pérez, Smriti Iyengar, Harlan E. Shannon, +24

Bioorganic & Medicinal Chemistry Letters

Pharmaceutical ScienceMedicinePain MedicineVitro ProfilePharmacological Agent +6