F. George Njoroge

SCH 503034, a Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease, Suppresses Polyprotein Maturation and Enhances the Antiviral Activity of Alpha Interferon in Replicon Cells

Bruce A. Malcolm, R. Liu, Frederick Lahser et al. · Antimicrobial Agents and Chemotherapy · 2006 · 318 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17

Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice.

Ming Liu, Matthew Bryant, Jianping Chen et al. · PubMed · 1998 · 309 citations

Medicine, Medicinal Chemistry, Pharmacology +15

Aging of Proteins: Immunological Detection of a Glucose-derived Pyrrole Formed during Maillard Reaction in vivo

Fumitaka Hayase, Ram H. Nagaraj, Satoshi Miyata et al. · Journal of Biological Chemistry · 1989 · 306 citations · Full text

Life Sciences, Biochemistry, Immunology +17

Discovery of (1 <i>R</i> ,5 <i>S</i> )- <i>N</i> -[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2( <i>S</i> )-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2( <i>S</i> )-carboxamide (SCH 503034), a Selective, Potent, Orally Bioavailable Hepatitis C Virus NS3 Protease Inhibitor:  A Potential Therapeutic Agent for the Treatment of Hepatitis C Infection

Srikanth Venkatraman, Stéphane Bogen, Ashok Arasappan et al. · Journal of Medicinal Chemistry · 2006 · 282 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Structural interaction of natural and synthetic inhibitors with the venom metalloproteinase, atrolysin C (form d).

Daizhou Zhang, Istvan Botos, F. Xavier Gomis‐Rüth et al. · Proceedings of the National Academy of Sciences · 1994 · 136 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17