Bruce A. Malcolm

Two-Stage PCR Protocol Allowing Introduction of Multiple Mutations, Deletions and Insertions Using QuikChange ^TM Site-Directed Mutagenesis

Wenyan Wang, Bruce A. Malcolm · BioTechniques · 1999 · 602 citations · Full text

Life Sciences, Biotechnology, Molecular Biology +15

SCH 503034, a Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease, Suppresses Polyprotein Maturation and Enhances the Antiviral Activity of Alpha Interferon in Replicon Cells

Bruce A. Malcolm, R. Liu, Frederick Lahser et al. · Antimicrobial Agents and Chemotherapy · 2006 · 318 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17

Picornaviral 3C cysteine proteinases have a fold similar to chymotrypsin-like serine proteinases

Marc Allaire, Maia M. Chernaia, Bruce A. Malcolm et al. · Nature · 1994 · 305 citations

Life Sciences, Biochemistry, Molecular Biology +10

Discovery of (1 <i>R</i> ,5 <i>S</i> )- <i>N</i> -[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2( <i>S</i> )-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2( <i>S</i> )-carboxamide (SCH 503034), a Selective, Potent, Orally Bioavailable Hepatitis C Virus NS3 Protease Inhibitor:  A Potential Therapeutic Agent for the Treatment of Hepatitis C Infection

Srikanth Venkatraman, Stéphane Bogen, Ashok Arasappan et al. · Journal of Medicinal Chemistry · 2006 · 282 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Ancestral lysozymes reconstructed, neutrality tested, and thermostability linked to hydrocarbon packing

Bruce A. Malcolm, Keith P. Wilson, Brian W. Matthews et al. · Nature · 1990 · 230 citations

Life Sciences, Biochemistry, Evolutionary Biology +12