Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice.

Ming Liu, Matthew Bryant, Jianping Chen, +21

PubMed

Sch 66336Chemoprevention StrategyFarnesyl Protein TransferaseOncogenic AgentMedicine +13

LGR5 Promotes Breast Cancer Progression and Maintains Stem-Like Cells Through Activation of Wnt/β-Catenin Signaling

Lu Yang, Hailin Tang, Yanan Kong, +8

Stem Cells

TC2N, a novel oncogene, accelerates tumor progression by suppressing p53 signaling pathway in lung cancer

Xianglin Hao, Fei Han, Ning Zhang, +10

Cell Death and Differentiation

Chronic treatment with a novel γ‐secretase modulator, JNJ‐40418677, inhibits amyloid plaque formation in a mouse model of Alzheimer's disease

Bianca Van Broeck, Jianping Chen, G Tréton, +6

British Journal of Pharmacology

Berberine Inhibits Growth and Induces G1 Arrest and Apoptosis in Human Cholangiocarcinoma QBC939 Cells

Wei He, Bin Wang, Yun Zhuang, +3

Journal of Pharmacological Sciences

Comprehensive molecular profiling of the B7 family of immune-regulatory ligands in breast cancer

Zhenyu Xu, Jing Shen, Maggie Haitian Wang, +12

OncoImmunology

Combination therapy with the farnesyl protein transferase inhibitor SCH66336 and SCH58500 (p53 adenovirus) in preclinical cancer models.

Loretta L. Nielsen, Bin Shi, Gerald Hajian, +8

PubMed

Tumor BiologyPreclinical Cancer ModelsThird DrugOncogenic AgentMedicine +13

Antitumor activity of HER1/EGFR tyrosine kinase inhibitor erlotinib, alone and in combination with CPT-11 (irinotecan) in human colorectal cancer xenograft models

Jianping Chen, Melissa Smith, Kenneth Kolinsky, +7

Cancer Chemotherapy and Pharmacology

Tumor BiologyAntitumor ActivityMedicinePharmacologyAnti-cancer Agent +4

Function and subsets of dendritic cells and natural killer cells were decreased in gastric cancer.

Jianping Chen, Jing Yang, Jingting Jiang, +2

PubMed

ImmunologyImmune RegulationPathologyImmunoeditingImmunologic Mechanism +22

Geranylgeranylacetone attenuates hepatic fibrosis by increasing the expression of heat shock protein 70

Wei He, Yun Zhuang, Liangzhi Wang, +5

Molecular Medicine Reports

Liver FibrosisPathologyHepatic FibrosisCholangiopathiesCcl4 Model Group +17