Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors

William C. Patt, Harriet W. Hamilton, Michael D. Taylor, +6

Journal of Medicinal Chemistry

Medicinal ChemistryHypertensionRenin InhibitorsMonkey ReninMedicine +11

Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants

Bryan D. Smith, Michael D. Kaufman, Wei-Ping Lu, +26

Cancer Cell

Pdgfra VariantsOncogenic AgentMedicineDrug-resistant KitReceptor Tyrosine Kinase +7

Conformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036

Wayne W. Chan, Scott Wise, Michael D. Kaufman, +24

Cancer Cell

Switch-control Inhibitor Dcc-2036Signal TransductionSignaling PathwayConformational Control InhibitionCell Regulation +7

Discovery of a Novel Series of Orally Active Non-Peptide Endothelin-A (ETA) Receptor-Selective Antagonists

Annette M. Doherty, William C. Patt, Jeremy J. Edmunds, +6

Journal of Medicinal Chemistry

ImmunologyAltmetric Attention ScorePeptide SciencePharmacotherapyPre-clinical Pharmacology +18

Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2

Bryan D. Smith, Michael D. Kaufman, Cynthia B. Leary, +20

Molecular Cancer Therapeutics

Switch Control PocketGliomaTumor BiologyAngiogenesisTumor Initiation +14

N6-Bicycloalkyladenosines with unusually high potency and selectivity for the adenosine A1 receptor

Bharat K. Trivedi, Alexander J. Bridges, William C. Patt, +2

Journal of Medicinal Chemistry

Pharmaceutical ScienceAltmetric Attention ScorePharmacotherapyAdenosine A1 ReceptorbMolecular Pharmacology +16

Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

Mark E. Schnute, Patrick O’Brien, Joe Nahra, +27

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesRational Drug Design +6

Ribose-modified adenosine analogs as adenosine receptor agonists

Michael D. Taylor, Walter H. Moos, Harriet W. Hamilton, +7

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryAdenosine A1Adenosine ReceptorsBiochemistry +12

Structure−Activity Relationships in a Series of Orally Active γ-Hydroxy Butenolide Endothelin Antagonists

William C. Patt, Jeremy J. Edmunds, Joseph T. Repine, +14

Journal of Medicinal Chemistry

Selective Antagonist Pd155080Pharmaceutical ScienceChemical BiologyExperimental PharmacologyMolecular Pharmacology +14

N6-Substituted adenosine receptor agonists: potential antihypertensive agents

Bharat K. Trivedi, C. John Blankley, James A. Bristol, +7

Journal of Medicinal Chemistry

Molecular PharmacologyHypertensionPotential Antihypertensive AgentsMolecular PhysiologyNovel N6-benzocycloalkyladenosines +11