William C. Patt

Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors

William C. Patt, Harriet W. Hamilton, Michael D. Taylor et al. · Journal of Medicinal Chemistry · 1992 · 373 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants

Bryan D. Smith, Michael D. Kaufman, Wei-Ping Lu et al. · Cancer Cell · 2019 · 277 citations

Medicine, Oncology, Pharmacology +17

Conformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036

Wayne W. Chan, Scott Wise, Michael D. Kaufman et al. · Cancer Cell · 2011 · 207 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Discovery of a Novel Series of Orally Active Non-Peptide Endothelin-A (ETA) Receptor-Selective Antagonists

Annette M. Doherty, William C. Patt, Jeremy J. Edmunds et al. · Journal of Medicinal Chemistry · 1995 · 109 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +11

Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2

Bryan D. Smith, Michael D. Kaufman, Cynthia B. Leary et al. · Molecular Cancer Therapeutics · 2015 · 77 citations

Medicine, Oncology, Pharmacology +17