Shuet‐Hing Lee Chiu

CYTOCHROME P450 3A4 IS THE MAJOR ENZYME INVOLVED IN THE METABOLISM OF THE SUBSTANCE P RECEPTOR ANTAGONIST APREPITANT

Rosa I. Sánchez, Regina W. Wang, Deborah J. Newton et al. · Drug Metabolism and Disposition · 2004 · 113 citations

Medicine, Pharmacokinetics, Pharmacology +16

In vitro metabolism of FK-506 in rat, rabbit, and human liver microsomes: Identification of a major metabolite and of cytochrome P450 3A as the major enzymes responsible for its metabolism

Styliani H. Vincent, Bindhu V. Karanam, Susan K. Painter et al. · Archives of Biochemistry and Biophysics · 1992 · 108 citations

Medicine, Pharmacokinetics, Pharmacology +17

Phosphorylated Morpholine Acetal Human Neurokinin-1 Receptor Antagonists as Water-Soluble Prodrugs

Jeffrey J. Hale, Sander G. Mills, Malcolm MacCoss et al. · Journal of Medicinal Chemistry · 2000 · 95 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +8

Use of on‐line hydrogen/deuterium exchange to facilitate metabolite identification

David Q. Liu, Cornelis E. C. A. Hop, Maria Beconi et al. · Rapid Communications in Mass Spectrometry · 2001 · 75 citations

Life Sciences, Biochemistry, Chemistry +15

Mechanism of bioactivation and covalent binding of 2,4,6-trinitrotoluene

Kwan Leung, Yao Ming, Ralph A. Stearns et al. · Chemico-Biological Interactions · 1995 · 73 citations

Natural Sciences, Chemistry, Toxicology +7