Bindhu V. Karanam

Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes

Margaret Wu, Sheo B. Singh, Jun Wang et al. · Proceedings of the National Academy of Sciences · 2011 · 145 citations

Fatty Acid Synthase, Insulin Signaling, Db/db Mice +16

In vitro metabolism of FK-506 in rat, rabbit, and human liver microsomes: Identification of a major metabolite and of cytochrome P450 3A as the major enzymes responsible for its metabolism

Styliani H. Vincent, Bindhu V. Karanam, Susan K. Painter et al. · Archives of Biochemistry and Biophysics · 1992 · 108 citations

Cytochrome P450 3A, Biochemistry, Medicine +13

Orally bioavailable, indole-based nonpeptide GnRH receptor antagonists with high potency and functional activity

Wallace T. Ashton, Rosemary M. Sisco, G. R. KIECZYKOWSKI et al. · Bioorganic & Medicinal Chemistry Letters · 2001 · 53 citations · Full text

Functional Activity, Functional Selectivity, High Potency +8

Benzazepinone Nav1.7 blockers: Potential treatments for neuropathic pain

Scott B. Hoyt, Clare London, Hyun Ok et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 46 citations · Full text

Molecular Pharmacology, Pain Therapy, Health Sciences +9

Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain

Harry R. Chobanian, Yan Guo, Ping Liu et al. · ACS Medicinal Chemistry Letters · 2014 · 41 citations · Full text

Pain Medicine, High Throughput, Neuropathic Pain +16