Concepedia

CYTOCHROME P450 3A4 IS THE MAJOR ENZYME INVOLVED IN THE METABOLISM OF THE SUBSTANCE P RECEPTOR ANTAGONIST APREPITANT

Rosa I. Sánchez, Regina W. Wang, Deborah J. Newton, Ray Bakhtiar, Ping Lü, Shuet‐Hing Lee Chiu, David Evans, Su-Er W. Huskey

Drug Metabolism and Disposition · 2004 · 113 citations · 20 references

DOI

Concepts

References

20

The Carbon Monoxide-binding Pigment of Liver Microsomes

Tsuneo Omura, Ryo Sato · Journal of Biological Chemistry · 1964 · 11.8K citations · Full text

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Recommendations for the Use of Antiemetics: Evidence-Based, Clinical Practice Guidelines

Richard J. Gralla, David Osoba, Mark G. Kris et al. · Journal of Clinical Oncology · 1999 · 670 citations

, , +15

Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.

Deborah J. Newton, R W Wang, Anthony Y.H. Lu · Drug Metabolism and Disposition · 1995 · 606 citations

, , +17

Reduction of Cisplatin-Induced Emesis by a Selective Neurokinin-1–Receptor Antagonist

Rudolph M. Navari, Rick R. Reinhardt, Richard J. Gralla et al. · New England Journal of Medicine · 1999 · 371 citations · Full text

, , +16

CYP3A4 drug interactions: correlation of 10 <i>in vitro</i> probe substrates

Kenworthy, Bloomer, Houston · British Journal of Clinical Pharmacology · 1999 · 337 citations · Full text

, , +17