Sam Lee

Pharmacology of a Central Nervous System Delivered 2′-O-Methoxyethyl–Modified Survival of Motor Neuron Splicing Oligonucleotide in Mice and Nonhuman Primates

Frank Rigo, Seung Chun, Daniel A. Norris et al. · Journal of Pharmacology and Experimental Therapeutics · 2014 · 275 citations · Full text

Medicine, Neuroscience, Pharmacology +14

Short Antisense Oligonucleotides with Novel 2′−4′ Conformationaly Restricted Nucleoside Analogues Show Improved Potency without Increased Toxicity in Animals

Punit P. Seth, Andrew Siwkowski, Charles Allerson et al. · Journal of Medicinal Chemistry · 2008 · 267 citations · Full text

Pharmacy, Molecular Biology, Pharmacology +17

Effects of Tenofovir Disoproxil Fumarate in Hepatitis B e Antigen-Positive Patients With Normal Levels of Alanine Aminotransferase and High Levels of Hepatitis B Virus DNA

Henry Lik‐Yuen Chan, C. K. Chan, Aric J. Hui et al. · Gastroenterology · 2014 · 173 citations · Full text

Pharmacy, Infectious Diseases, Pharmacology +14

Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages

Michael T. Migawa, Guillermo Vasquez, Heather Murray et al. · Nucleic Acids Research · 2014 · 129 citations · Full text

Pharmacy, Biochemistry, Chemistry +16

Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver

Brad G. Hoffman, Gordon Robertson, Bogard Zavaglia et al. · Genome Research · 2010 · 118 citations · Full text

Life Sciences, Genetics, Molecular Biology +17