An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED

Wei Qi, Kehao Zhao, Justin Gu, +37

Nature Chemical Biology

Signal TransductionSignaling PathwayCell RegulationReceptor Tyrosine KinaseReceptor (Biochemistry) +5

Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy

Ying Huang, Jeff Zhang, Zhengtian Yu, +31

Journal of Medicinal Chemistry

NSD2 Is Recruited through Its PHD Domain to Oncogenic Gene Loci to Drive Multiple Myeloma

Zheng Huang, Haiping Wu, Shannon Chuai, +25

Cancer Research

Structure of Human SMYD2 Protein Reveals the Basis of p53 Tumor Suppressor Methylation

Li Wang, Ling Li, Hailong Zhang, +8

Journal of Biological Chemistry

Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2

Jeffrey W. Corbett, Kevin D. Freeman‐Cook, Richard L. Elliott, +21

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryNatural SciencesMedicineDrug Development +7

Methylation of RASSF1A gene promoter is regulated by p53 and DAXX

Hailong Zhang, Jing He, Jiansha Li, +3

The FASEB Journal

Identification of a Glutamatergic Claustrum-Anterior Cingulate Cortex Circuit for Visceral Pain Processing

Qiya Xu, Hailong Zhang, Han Du, +4

Journal of Neuroscience

Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED

Ling Li, Hailong Zhang, Man Zhang, +24

PLoS ONE

Histone ModificationsHistone H3Drug TargetEpigenetic ChangeNovel Eed Binder +22

Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies

Ying Huang, Martin Sendzik, Jeff Zhang, +38

Journal of Medicinal Chemistry

Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain

Guillermo Senisterra, Hugh Zhu, Xiao Luo, +17

SLAS DISCOVERY