Hailong Zhang

An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED

Wei Qi, Kehao Zhao, Justin Gu et al. · Nature Chemical Biology · 2017 · 313 citations · Full text

Signal Transduction, Signaling Pathway, Cell Regulation +7

Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy

Ying Huang, Jeff Zhang, Zhengtian Yu et al. · Journal of Medicinal Chemistry · 2017 · 100 citations · Full text

NSD2 Is Recruited through Its PHD Domain to Oncogenic Gene Loci to Drive Multiple Myeloma

Zheng Huang, Haiping Wu, Shannon Chuai et al. · Cancer Research · 2013 · 72 citations

Structure of Human SMYD2 Protein Reveals the Basis of p53 Tumor Suppressor Methylation

Li Wang, Ling Li, Hailong Zhang et al. · Journal of Biological Chemistry · 2011 · 65 citations · Full text

Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2

Jeffrey W. Corbett, Kevin D. Freeman‐Cook, Richard L. Elliott et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 58 citations · Full text

Medicinal Chemistry, Biochemistry, Natural Sciences +9