Justin Gu

Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks

Frank W. Schmitges, Archana Bairavasundaram Prusty, Mahamadou Faty et al. · Molecular Cell · 2011 · 745 citations · Full text

Life Sciences, Genetics, Molecular Biology +13

Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

Konstantinos J. Mavrakis, E. Robert McDonald, Michael R. Schlabach et al. · Science · 2016 · 580 citations

Medicine, Cancer Biology, Oncology +16

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

Wei Qi, Homan Chan, Lin Teng et al. · Proceedings of the National Academy of Sciences · 2012 · 545 citations · Full text

Life Sciences, Molecular Biology, Oncology +17

An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED

Wei Qi, Kehao Zhao, Justin Gu et al. · Nature Chemical Biology · 2017 · 321 citations · Full text

Medicine, Molecular Biology, Pharmacology +7

Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy

Ying Huang, Jeff Zhang, Zhengtian Yu et al. · Journal of Medicinal Chemistry · 2017 · 103 citations · Full text

Medicine, Oncology, Pharmacology +17