Concepedia

Justin Gu

JG

11

Publications

2.6K

Citations

11

H-Index

2011

Active since

Affiliations

Novartis (China)(Current)

Novartis (United States)

Novartis (Switzerland)

Novartis Institutes for BioMedical Research

Justin Gu is an author at Novartis (China) specializing in medicine, cell biology, and molecular biology.

Top concepts

MedicineCell BiologyEpigeneticsMolecular BiologyChromatinEpigenomicsTumor BiologyNatural SciencesEpigenetic RegulationHistone Modifications

Publications per year

2011–2022

11

Publications

11

Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks

Frank W. Schmitges, Archana Bairavasundaram Prusty, Mahamadou Faty et al. · Molecular Cell · 2011 · 734 citations · Full text

Histone Modifications, Chromatin, Chromatin Remodeling +14

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

Wei Qi, Homan Chan, Lin Teng et al. · Proceedings of the National Academy of Sciences · 2012 · 542 citations · Full text

Selective Inhibition, Tumor Biology, Methyl Group +15

Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

Konstantinos J. Mavrakis, E. Robert McDonald, Michael R. Schlabach et al. · Science · 2016 · 538 citations

An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED

Wei Qi, Kehao Zhao, Justin Gu et al. · Nature Chemical Biology · 2017 · 313 citations · Full text

Signal Transduction, Signaling Pathway, Cell Regulation +7

Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy

Ying Huang, Jeff Zhang, Zhengtian Yu et al. · Journal of Medicinal Chemistry · 2017 · 100 citations · Full text

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