Zhengtian Yu

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

Wei Qi, Homan Chan, Lin Teng et al. · Proceedings of the National Academy of Sciences · 2012 · 542 citations · Full text

Selective Inhibition, Tumor Biology, Methyl Group +15

An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED

Wei Qi, Kehao Zhao, Justin Gu et al. · Nature Chemical Biology · 2017 · 313 citations · Full text

Signal Transduction, Signaling Pathway, Cell Regulation +7

Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia

Jacob D. Jaffe, Yan Wang, Ho Man Chan et al. · Nature Genetics · 2013 · 281 citations · Full text

Chromatin, Chromatin Structure, Chromatin Remodeling +8

Histone methyltransferase SETDB1 regulates liver cancer cell growth through methylation of p53

Qi Fei, Ke Shang, Jianhua Zhang et al. · Nature Communications · 2015 · 161 citations · Full text

Histone Modifications, Epigenetic Change, Epigenetics +16

Development of secondary mutations in wild-type and mutant EZH2 alleles cooperates to confer resistance to EZH2 inhibitors

Veronica Gibaja, F Shen, J Harari et al. · Oncogene · 2015 · 142 citations · Full text

Genetics, Molecular Biology, Molecular Genetics +21