Therapeutic antibody targeting of individual Notch receptors

Yan Wu, Carol Cain-Hom, Lisa Choy, +21

Nature

ImmunologyReceptor (Biochemistry)ImmunochemistryAntibody EngineeringImmunotherapy +3

An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED

Wei Qi, Kehao Zhao, Justin Gu, +37

Nature Chemical Biology

Signal TransductionSignaling PathwayCell RegulationReceptor Tyrosine KinaseReceptor (Biochemistry) +5

Medical large language models are vulnerable to data-poisoning attacks

Daniel Alexander Alber, Zihao Yang, Anton Alyakin, +29

Nature Medicine

Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy

Ying Huang, Jeff Zhang, Zhengtian Yu, +31

Journal of Medicinal Chemistry

Insights into Mechanism of Glucokinase Activation

Shenping Liu, Mark Ammirati, Xi Song, +5

Journal of Biological Chemistry

Protein FunctionSignal TransductionMolecular PhysiologyBiochemistryG Protein-coupled Receptor +8

Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach

Chao Chen, Hugh Zhu, Frédéric Stauffer, +14

ACS Medicinal Chemistry Letters

Drug TargetMolecular BiologyChemical BiologyPharmaceutical ChemistryRecruit Dot1l +18

Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies

Ying Huang, Martin Sendzik, Jeff Zhang, +38

Journal of Medicinal Chemistry

The effects of ramelteon in a first-night model of transient insomnia

Gary Zammit, Howard Schwartz, Thomas Roth, +3

Sleep Medicine

Sleep DisordersSleepNeurophysiologyPhysiologySocial Sciences +7

Long‐term Safety of Pioglitazone versus Glyburide in Patients with Recently Diagnosed Type 2 Diabetes Mellitus

Rajeev Jain, Kwame Osei, Stuart Kupfer, +2

Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy

Self-reported efficacy and tolerability of ramelteon 8 mg in older adults experiencing severe sleep-onset difficulty

Louis J. Mini, Sherry Wang‐Weigand, Jeff Zhang

˜The œAmerican journal of geriatric pharmacotherapy

Sleep DisordersSleep HealthSleep MedicineSleepSleep Disorder +9