Frederick Cohen

USP7 small-molecule inhibitors interfere with ubiquitin binding

Lorna Kategaya, Paola Di Lello, Lionel Rougé et al. · Nature · 2017 · 332 citations · Full text

Molecular Docking, Ubiquitin Binding, Drug Target +7

Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

John A. Flygare, Maureen H. Beresini, Nageshwar Budha et al. · Journal of Medicinal Chemistry · 2012 · 247 citations · Full text

Apoptosis, Cell Death, Clinical Candidate +20

Enantioselective Total Synthesis of Batzelladine F:  Structural Revision and Stereochemical Definition

Frederick Cohen, Larry E. Overman · Journal of the American Chemical Society · 2001 · 87 citations

Chemical Engineering, Engineering, Structural Revision +11

Discovery of Dual Leucine Zipper Kinase (DLK, MAP3K12) Inhibitors with Activity in Neurodegeneration Models

Snahel Patel, Frederick Cohen, Brian J. Dean et al. · Journal of Medicinal Chemistry · 2014 · 86 citations · Full text

Cell Death, Neurodegeneration Models, Signaling Pathway +20

Discovery of Small-Molecule Inhibitors of Ubiquitin Specific Protease 7 (USP7) Using Integrated NMR and in Silico Techniques

Paola Di Lello, Richard Pastor, Jeremy Murray et al. · Journal of Medicinal Chemistry · 2017 · 86 citations · Full text