Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127

Skye Montoya, Jessie Bourcier, Mark Noviski, +50

Science

EngineeringMixed-phenotype Acute LeukemiaGeneticsDisease Gene IdentificationMyeloid Neoplasia +15

IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate

Mark Noviski, James L. Mueller, Anne B. Satterthwaite, +3

eLife

NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting

Corey Tan, Ryosuke Hiwa, James L. Mueller, +10

Nature Immunology

B Cell ResponsesSignal TransductionAdaptive Immune SystemG Protein-coupled ReceptorImmunology +9

Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton’s Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B Cell Malignancies

Daniel Robbins, Mark Noviski, Ying Siow Tan, +30

Journal of Medicinal Chemistry

Nx-2127, a Degrader of BTK and IMiD Neosubstrates, for the Treatment of B-Cell Malignancies

Daniel Robbins, Aileen Kelly, May Tan, +21

Blood

Nx-5948, a Selective Degrader of BTK with Activity in Preclinical Models of Hematologic and Brain Malignancies

Daniel Robbins, Mark Noviski, Ryan B. Rountree, +13

Blood

Nur77 Links Chronic Antigen Stimulation to B Cell Tolerance by Restricting the Survival of Self-Reactive B Cells in the Periphery

Corey Tan, James L. Mueller, Mark Noviski, +6

The Journal of Immunology

An extracatalytic function of CD45 in B cells is mediated by CD22

Sarah Coughlin, Mark Noviski, James L. Mueller, +4

Proceedings of the National Academy of Sciences

NRX-0492 degrades wild-type and C481 mutant BTK and demonstrates in vivo activity in CLL patient-derived xenografts

Deyi Zhang, Hailey M. Harris, Jonathan Chen, +21

Blood

Optimal Development of Mature B Cells Requires Recognition of Endogenous Antigens

Mark Noviski, Corey Tan, John Huizar, +3

The Journal of Immunology

Lymphocyte DevelopmentAdaptive Immune SystemBcr Signal TransductionImmunologyHumoral Response +19