Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease

Claire E. Le Pichon, William J. Meilandt, Sara L. Domínguez, +26

Science Translational Medicine

RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases

Snahel Patel, Joshua D. Webster, Eugene Varfolomeev, +22

Cell Death and Differentiation

ImmunologyPathologyCell DeathKinase Rip1Cancer Biology +14

Discovery of Dual Leucine Zipper Kinase (DLK, MAP3K12) Inhibitors with Activity in Neurodegeneration Models

Snahel Patel, Frederick Cohen, Brian J. Dean, +24

Journal of Medicinal Chemistry

Cell DeathNeurodegeneration ModelsSignaling PathwayReceptor Tyrosine KinaseAutophagy +18

Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer’s Disease

Snahel Patel, William J. Meilandt, Rebecca I. Erickson, +16

Journal of Medicinal Chemistry

Selective InhibitorsAlzheimer ’Superior Kinase SelectivityMolecular PharmacologyMedicinal Chemistry +17

Deep learning detects cardiotoxicity in a high-content screen with induced pluripotent stem cell-derived cardiomyocytes

Francis Grafton, Jaclyn J. Ho, Sara Ranjbarvaziri, +9

eLife

Cardiac MuscleConvolutional Neural NetworkEngineeringMachine LearningBiomedical Engineering +19

Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant <i>N</i> -(1 <i>H</i> -Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12)

Snahel Patel, Seth F. Harris, Paul Gibbons, +17

Journal of Medicinal Chemistry

From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors

Jun Liang, Sharada S. Labadie, Birong Zhang, +23

Bioorganic & Medicinal Chemistry Letters

Bioavailable Kdm5 InhibitorsDrug TargetBiochemistryMedicineNovel Hts Hit +5

Quinazolin-4-piperidin-4-methyl sulfamide PC-1 inhibitors: Alleviating hERG interactions through structure based design

Snahel Patel, Wendy M. Habeski, Alan C. Cheng, +3

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesPharmacology +8

Phenotypic screening with deep learning identifies HDAC6 inhibitors as cardioprotective in a BAG3 mouse model of dilated cardiomyopathy

Jin Yang, Francis Grafton, Sara Ranjbarvaziri, +12

Science Translational Medicine

Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors

Mark Zak, Po‐wai Yuen, Xiongcai Liu, +17

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryCyp2c9 InhibitionDrug TargetBiochemistry +13