Herman de Kock

Discovery and Development of Simeprevir (TMC435), a HCV NS3/4A Protease Inhibitor

Åsa Rosenquist, Bertil Samuelsson, Per-Ola Johansson et al. · Journal of Medicinal Chemistry · 2014 · 215 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

<i>In Vitro</i> Resistance Profile of the Hepatitis C Virus NS3/4A Protease Inhibitor TMC435

Oliver Lenz, Thierry Verbinnen, Tse‐I Lin et al. · Antimicrobial Agents and Chemotherapy · 2010 · 211 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17

In Vitro Activity and Preclinical Profile of TMC435350, a Potent Hepatitis C Virus Protease Inhibitor

Tse‐I Lin, Oliver Lenz, Gregory Fanning et al. · Antimicrobial Agents and Chemotherapy · 2009 · 190 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Rapid HCV-RNA Decline With Once Daily TMC435: A Phase I Study in Healthy Volunteers and Hepatitis C Patients

H. W. Reesink, Gregory Fanning, Khalid Abou Farha et al. · Gastroenterology · 2009 · 155 citations · Full text

Life Sciences, Infectious Diseases, Microbiology +14

Structure–activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350

Pierre Raboisson, Herman de Kock, Åsa Rosenquist et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 136 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16