MAIT cells are activated during human viral infections

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Nature Communications

Comparison of the substrate specificities of human thymidine kinase 1 and 2 and deoxycytidine kinase toward antiviral and cytostatic nucleoside analogs

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Biochemical and Biophysical Research Communications

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Discovery and Development of Simeprevir (TMC435), a HCV NS3/4A Protease Inhibitor

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Journal of Medicinal Chemistry

Hepatitis C VirusImmunologyPharmacotherapyImmunotherapeuticsAntiviral Drug +18

<i>In Vitro</i> Resistance Profile of the Hepatitis C Virus NS3/4A Protease Inhibitor TMC435

Oliver Lenz, Thierry Verbinnen, Tse‐I Lin, +16

Antimicrobial Agents and Chemotherapy

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In Vitro Activity and Preclinical Profile of TMC435350, a Potent Hepatitis C Virus Protease Inhibitor

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Antimicrobial Agents and Chemotherapy

Cathepsin S Causes Inflammatory Pain via Biased Agonism of PAR2 and TRPV4

Peishen Zhao, TinaMarie Lieu, Νicholas Barlow, +16

Journal of Biological Chemistry

HIV-1-Specific Reverse Transcriptase Inhibitors Show Differential Activity against HIV-1 Mutant Strains Containing Different Amino Acid Substitutions in the Reverse Transcriptase

Jan Balzarini, Anna Karlsson, María‐Jesús Pérez‐Pérez, +7

Virology

Human RetrovirusAntiviral Drug DevelopmentReverse TranscriptaseMolecular BiologyVirology +7

Relationships between Structure and Interaction Kinetics for HIV-1 Protease Inhibitors

Per-Olof Markgren, Wesley Schaal, Markku Hämäläinen, +4

Journal of Medicinal Chemistry

Drug TargetMolecular BiologyAntiviral DrugChemical BiologyPharmaceutical Chemistry +18

Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus

M. Azim Ansari, Vincent Pedergnana, Camilla L. C. Ip, +13

Nature Genetics

Human InnateHepatitis C VirusViral HepatitisPathogenesisImmunology +9

Structural basis for the inhibitory efficacy of efavirenz (DMP‐266), MSC194 and PNU142721 towards the HIV‐1 RT K103N mutant

Jimmy Lindberg, Snævar Sigurðsson, Seved Löwgren, +6

European Journal of Biochemistry