Lotta Vrang

<i>In Vitro</i> Resistance Profile of the Hepatitis C Virus NS3/4A Protease Inhibitor TMC435

Oliver Lenz, Thierry Verbinnen, Tse‐I Lin et al. · Antimicrobial Agents and Chemotherapy · 2010 · 210 citations · Full text

Molecular Virology, Viral Hepatitis, Pathogenesis +14

In Vitro Activity and Preclinical Profile of TMC435350, a Potent Hepatitis C Virus Protease Inhibitor

Tse‐I Lin, Oliver Lenz, Gregory Fanning et al. · Antimicrobial Agents and Chemotherapy · 2009 · 190 citations · Full text

HIV-1-Specific Reverse Transcriptase Inhibitors Show Differential Activity against HIV-1 Mutant Strains Containing Different Amino Acid Substitutions in the Reverse Transcriptase

Jan Balzarini, Anna Karlsson, María‐Jesús Pérez‐Pérez et al. · Virology · 1993 · 153 citations

Human Retrovirus, Antiviral Drug Development, Reverse Transcriptase +9

Structure–activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350

Pierre Raboisson, Herman de Kock, Åsa Rosenquist et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 136 citations

Novel Series, Biochemistry, Structure–activity Relationship Study +7

Phenethylthiazolylthiourea (PETT) Compounds as a New Class of HIV-1 Reverse Transcriptase Inhibitors. 2. Synthesis and Further Structure−Activity Relationship Studies of PETT Analogs

Amanda Cantrell, Per Engelhardt, Marita Högberg et al. · Journal of Medicinal Chemistry · 1996 · 111 citations · Full text

Cell Culture, Organic Chemistry, Heterocycle Chemistry +16