Concepedia

Structure–activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350

Pierre Raboisson, Herman de Kock, Åsa Rosenquist, Magnus Nilsson, Lourdes Salvador-Oden, Tse‐I Lin, Natalie Roue, Horst Wähling, Kristina Wickström, Elizabeth Hamelink,

Bioorganic & Medicinal Chemistry Letters · 2008 · 136 citations · 17 references

DOI

Concepts

References

17

Peginterferon Alfa-2a plus Ribavirin for Chronic Hepatitis C Virus Infection

Michael Fried, Mitchell L. Shiffman, K. Rajender Reddy et al. · New England Journal of Medicine · 2002 · 6.4K citations

, , +17

The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products

Oyo Mitsunobu · Synthesis · 1981 · 4.1K citations

, , +8

A Recyclable Ru-Based Metathesis Catalyst

Jason S. Kingsbury, Joseph P. A. Harrity, Peter J. Bonitatibus et al. · Journal of the American Chemical Society · 1999 · 938 citations

, , +16

Viral and Cellular Determinants of Hepatitis C Virus RNA Replication in Cell Culture

Volker Lohmann, Sandra Hoffmann, Ulrike Herian et al. · Journal of Virology · 2003 · 390 citations · Full text

, , +14

Short-term antiviral efficacy of BILN 2061, a hepatitis C virus serine protease inhibitor, in hepatitis C genotype 1 patients

Holger Hinrichsen, Yves Benhamou, Heiner Wedemeyer et al. · Gastroenterology · 2004 · 331 citations · Full text

, , +12