Aristos J. Alexandrou

Pharmacological reversal of a pain phenotype in iPSC-derived sensory neurons and patients with inherited erythromelalgia

Lishuang Cao, Aoibhinn McDonnell, Anja Nitzsche et al. · Science Translational Medicine · 2016 · 195 citations

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release

Aristos J. Alexandrou, Adam R. Brown, Mark L. Chapman et al. · PLoS ONE · 2016 · 187 citations · Full text

A novel selective and orally bioavailable <scp>N</scp> a <scp> _v </scp> 1.8 channel blocker, <scp>PF</scp> ‐01247324, attenuates nociception and sensory neuron excitability

C. Elizabeth Payne, Adam R. Brown, Jonathon W Theile et al. · British Journal of Pharmacology · 2015 · 96 citations · Full text

An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes

Lily T.-Y. Cho, Aristos J. Alexandrou, Rubben Torella et al. · Structure · 2018 · 37 citations · Full text

Molecular Physiology, Signal Transduction, Biochemistry +13

Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes

Richard Storer, Andy Pike, Nigel A. Swain et al. · Bioorganic & Medicinal Chemistry Letters · 2017 · 27 citations · Full text

Medicinal Chemistry, Pharmaceutical Science, Chemical Probes +12