A novel selective and orally bioavailable <scp>N</scp> a <scp> _v </scp> 1.8 channel blocker, <scp>PF</scp> ‐01247324, attenuates nociception and sensory neuron excitability

Abstract

Using PF-01247324, we have confirmed a role for Nav 1.8 channels in both inflammatory and neuropathic pain. We have also demonstrated a key role for Nav 1.8 channels in action potential upstroke and repetitive firing of rat and human DRG neurons.