David Printzenhoff

Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

Ken McCormack, Sonia Santos, Mark L. Chapman et al. · Proceedings of the National Academy of Sciences · 2013 · 243 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release

Aristos J. Alexandrou, Adam R. Brown, Mark L. Chapman et al. · PLoS ONE · 2016 · 194 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

A novel selective and orally bioavailable <scp>N</scp> a <scp> _v </scp> 1.8 channel blocker, <scp>PF</scp> ‐01247324, attenuates nociception and sensory neuron excitability

C. Elizabeth Payne, Adam R. Brown, Jonathon W Theile et al. · British Journal of Pharmacology · 2015 · 101 citations · Full text

Medicine, Neurobiology, Pharmacology +14

Discovery of Clinical Candidate 4-[2-(5-Amino-1<i>H</i>-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-<i>N</i>-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na_V1.7

Nigel A. Swain, D. V. Batchelor, Serge Beaudoin et al. · Journal of Medicinal Chemistry · 2017 · 83 citations · Full text

Pharmacy, Clinical Pharmacokinetics, Pharmacology +17

Biophysical and Pharmacological Characterization of Nav1.9 Voltage Dependent Sodium Channels Stably Expressed in HEK-293 Cells

Zhixin Lin, Sonia Santos, Karen Padilla et al. · PLoS ONE · 2016 · 53 citations · Full text

Natural Sciences, Pharmacology, Physiology +17