Nigel A. Swain

Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

Ken McCormack, Sonia Santos, Mark L. Chapman et al. · Proceedings of the National Academy of Sciences · 2013 · 240 citations · Full text

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release

Aristos J. Alexandrou, Adam R. Brown, Mark L. Chapman et al. · PLoS ONE · 2016 · 187 citations · Full text

Aromatic chloride to nitrile transformation: medicinal and synthetic chemistry

Lyn H. Jones, Nicholas W. Summerhill, Nigel A. Swain et al. · MedChemComm · 2010 · 88 citations

Medicinal Chemistry, Aromatic Chloride, Heterocyclic +12

Discovery of Clinical Candidate 4-[2-(5-Amino-1<i>H</i>-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-<i>N</i>-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na_V1.7

Nigel A. Swain, D. V. Batchelor, Serge Beaudoin et al. · Journal of Medicinal Chemistry · 2017 · 82 citations · Full text

Novel Indazole Non-Nucleoside Reverse Transcriptase Inhibitors Using Molecular Hybridization Based on Crystallographic Overlays

Lyn H. Jones, Gill Allan, Oscar Barba et al. · Journal of Medicinal Chemistry · 2009 · 55 citations · Full text

Combinatorial Chemistry, Molecular Biology, Pharmacotherapy +16