Andy Pike

Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper

Giuditta Illuzzi, Anna D. Staniszewska, Sonja J. Gill et al. · Clinical Cancer Research · 2022 · 171 citations · Full text

Medicine, Oncology, Pharmacology +13

Changes in Mammographic Densities Induced by a Hormonal Contraceptive Designed to Reduce Breast Cancer Risk

Darcy Spicer, Giske Ursin, Yuri R. Parisky et al. · JNCI Journal of the National Cancer Institute · 1994 · 144 citations

Medicine, Endocrinology, Gynecology +17

Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies

Bernard Barlaam, Robert Casella, Justin Cidado et al. · Journal of Medicinal Chemistry · 2020 · 104 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Discovery of Clinical Candidate 4-[2-(5-Amino-1<i>H</i>-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-<i>N</i>-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na_V1.7

Nigel A. Swain, D. V. Batchelor, Serge Beaudoin et al. · Journal of Medicinal Chemistry · 2017 · 83 citations · Full text

Pharmacy, Clinical Pharmacokinetics, Pharmacology +17

Pharmacology in translation: the preclinical and early clinical profile of the novel α2/3 functionally selective GABA_A receptor positive allosteric modulator PF‐06372865

Sarah A. Nickolls, Rachel Gurrell, Guido van Amerongen et al. · British Journal of Pharmacology · 2017 · 65 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15