Giuditta Illuzzi

Combined PARP and ATR inhibition potentiates genome instability and cell death in ATM-deficient cancer cells

Rebecca L. Lloyd, Paul W.G. Wijnhoven, Antonio Ramos‐Montoya et al. · Oncogene · 2020 · 186 citations · Full text

Life Sciences, Cancer Biology, Oncology +17

Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper

Giuditta Illuzzi, Anna D. Staniszewska, Sonja J. Gill et al. · Clinical Cancer Research · 2022 · 171 citations · Full text

Medicine, Oncology, Pharmacology +13

Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-<i>N</i>-methylpyridine-2-carboxamide (AZD5305): A PARP1–DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs

Jeffrey W. Johannes, Amber Balazs, Derek Barratt et al. · Journal of Medicinal Chemistry · 2021 · 140 citations · Full text

Life Sciences, Medicinal Chemistry, Oncology +13

PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways

Carole Beck, Christian Boehler, Josée Guirouilh‐Barbat et al. · Nucleic Acids Research · 2014 · 98 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress

Giuditta Illuzzi, Elise Fouquerel, Jean‐Christophe Amé et al. · Nucleic Acids Research · 2014 · 83 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17