David N. Johnston

Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I

Lee D. Arnold, David J. Calderwood, R. W. Dixon et al. · Bioorganic & Medicinal Chemistry Letters · 2000 · 93 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Biochemistry +8

Structure-Based Design of Novel 2-Amino-6-phenyl-pyrimido[5′,4′:5,6]pyrimido[1,2-<i>a</i>]benzimidazol-5(6<i>H</i>)-ones as Potent and Orally Active Inhibitors of Lymphocyte Specific Kinase (Lck): Synthesis, SAR, and In Vivo Anti-Inflammatory Activity

Matthew W. Martin, John Newcomb, Joseph J. Nunes et al. · Journal of Medicinal Chemistry · 2008 · 62 citations · Full text

Drug Target, Immunology, Lymphocyte Specific Kinase +20

Novel 2-Aminopyrimidine Carbamates as Potent and Orally Active Inhibitors of Lck:  Synthesis, SAR, and in Vivo Antiinflammatory Activity

Matthew W. Martin, John Newcomb, Joseph J. Nunes et al. · Journal of Medicinal Chemistry · 2006 · 60 citations · Full text

Immunology, Pharmacotherapy, Immunotherapy +18

Pyrrolo[2,3-d]pyrimidines containing diverse N-7 substituents as potent inhibitors of Lck

David J. Calderwood, David N. Johnston, Rainer Munschauer et al. · Bioorganic & Medicinal Chemistry Letters · 2002 · 53 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Biochemistry +9

Pyrrolo[2,3-d]pyrimidines Containing an Extended 5-Substituent as Potent and Selective Inhibitors of lck II

Andrew Burchat, David J. Calderwood, Gavin C. Hirst et al. · Bioorganic & Medicinal Chemistry Letters · 2000 · 51 citations

Combinatorial Chemistry, Medicinal Chemistry, Biochemistry +9