John Newcomb

A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment

Marc L. Hyer, Michael A. Milhollen, Jeff Ciavarri et al. · Nature Medicine · 2018 · 414 citations

Medicine, Anti-cancer Agent, Small-molecule Inhibitor +8

HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides

Janice M. Riberdy, John Newcomb, Michael J. Surman et al. · Nature · 1992 · 379 citations

Histocompatibility, Human Leukocyte Antigen, Invariant Chain Peptides +12

Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors

Xiaotian Zhu, Joseph L. Kim, John Newcomb et al. · Structure · 1999 · 255 citations · Full text

Signal Transduction, Receptor Tyrosine Kinase, Molecular Biology +8

Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor

Xingyue He, Jessica Riceberg, Teresa A. Soucy et al. · Nature Chemical Biology · 2017 · 223 citations

Selective Sae Inhibitor, Oncogenic Agent, Medicine +10

Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles.

Sebastián Amigorena, Paul Webster, James R. Drake et al. · The Journal of Experimental Medicine · 1995 · 145 citations · Full text

Proteinlipid Interaction, Immunology, Molecular Biology +20