Gavin C. Hirst

Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases

Scott J. Hecker, K. Raja Reddy, Maxim Totrov et al. · Journal of Medicinal Chemistry · 2015 · 405 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

First total synthesis of Lycopodium alkaloids of the magellanane group. Enantioselective total syntheses of (-)-magellanine and (+)-magellaninone

Gavin C. Hirst, Theodore Johnson, Larry E. Overman · Journal of the American Chemical Society · 1993 · 129 citations

Natural Sciences, Chemistry, Medicinal Chemistry +7

Discovery of 1,5-Benzodiazepines with Peripheral Cholecystokinin (CCK-A) Receptor Agonist Activity. 1. Optimization of the Agonist “Trigger”

Christopher Aquino, Duncan Armour, Judd Berman et al. · Journal of Medicinal Chemistry · 1996 · 101 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Optimization of 3-(1<i>H</i>-Indazol-3-ylmethyl)-1,5-benzodiazepines as Potent, Orally Active CCK-A Agonists

Brad R. Henke, Christopher Aquino, Larry S. Birkemo et al. · Journal of Medicinal Chemistry · 1997 · 86 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection

Andrew Burchat, David W. Borhani, David J. Calderwood et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 85 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14